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Technical articles
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High Sensitivity EtG and EtS Method Reduces Costs and Analysis Time |
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High Sensitivity EtG and EtS Method Reduces Costs and Analysis Time
By Amanda Rigdon, Clinical/Forensic Innovations Chemist, Steve Kozel, LC Column Product Marketing Manager, and Becky Wittrig, Ph.D., Global HPLC Specialist
- Increase retention for ethyl glucuronide and ethyl sulfate in half the overall analysis time.
- Improve LC/MS sensitivity with increased organic mobile phase.
- Reduce cost of materials with minimal sample prep and short analytical column.
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Pesticides in Dietary Supplements |
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Pesticides in Dietary Supplements:
Advantages of QuEChERS vs. PAM 303
By Julie Kowalski, Innovations Chemist, Michelle Misselwitz, Innovations Chemist, Jason Thomas, Innovations Chemist, Jack Cochran, Director of New Business and Technology
- Simple, cost-effective QuEChERS approach saves time and uses 20x less solvent.
- GMP-friendly—prepackaged extraction salts and snap-and-shoot standards reduce human error.
- Cartridge SPE cleanup removes matrix interferences, assuring accurate pesticide determination.
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Two Options for Analyzing Potential Genotoxic Impurities in Active Pharmaceutical Ingredients |
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Two Options for Analyzing Potential Genotoxic Impurities in Active Pharmaceutical Ingredients
By Amanda Rigdon, Pharmaceutical Innovations Chemist, Rick Lake, Pharmaceutical Market Development Manager, Claire Heechoon*, Research Chemist, Roy Helmy*, Ph.D., Research Fellow, Christopher Strulson*, Research Assistant, and Margaret Figus*, Research Chemist
*Merck & Co., Inc.
Laboratory needs for analyzing PGIs in API vary. Here we developed both a fast analysis of sulfonate esters on the Rxi®-5Sil MS column, and a comprehensive method for sulfonate esters and alkyl halides on the Rtx®-200 column.
Compounds that are used in the synthesis of active pharmaceutical ingredients (API), or reaction byproducts that form during synthesis, have the potential to remain as impurities. Some of these compounds are potentially genotoxic impurities (PGI) and may raise concern about cancer and/or birth defects.
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Develop More Productive PPCP Methods with a Single Ultra II® Aromax Column |
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Develop More Productive PPCP Methods by Replacing C18 and HILIC Columns with a Single Ultra II® Aromax Column
By Michelle Misselwitz, Innovations Chemist, Steve Kozel, HPLC Marketing Manager, Julie Kowalski, Innovations Chemist, Becky Wittrig, Ph.D., Global HPLC Specialist, and Amanda Rigdon, Innovations Chemist
- Use 1 column instead of 2—no need for separate HILIC analysis.
- Better response than on a C18; higher retention reduces ion suppression from coeluting compounds.
- Lower detection limits—highly organic mobile phase improves sensitivity.
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Accurately Quantify Methanol and Ethanol in E85 Biofuel by D5501 with New Rtx®-DHA-150 Column
By Barry Burger, Petroleum Innovations Chemist, Jaap de Zeeuw, International GC Specialist, and Jan Pijpelink, Petrochemical Market Development Manager
Content previously published in Petro Industry News
Ethanol and methanol levels in biofuels must be accurately determined as they impact fuel performance and influence sales price. Since fuel ethanol must be denatured with gasoline to render it nonpotable prior to transport, analysis is complicated by the presence of gasoline hydrocarbons. Testing is usually done according to ASTM Method D5501, which recommends either a 100m or a 150m column. This method currently targets the determination of ethanol at 93-97% and methanol at 0.1-0.6%, based on mass percent in product; however, discussions have been initiated to expand the range to 20-99%. The main challenge in ASTM D5501 is getting clean elution of both ethanol and methanol, without the coelution of components from the gasoline denaturant. Coelution of methanol and isobutane is particularly problematic and may require time-consuming cryogenic conditions.
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