Active basic compounds that otherwise require derivatization, or an alternative analytical technique, can be analyzed on an Rtx®-5 Amine column. The tubing surface is chemically altered to reduce tailing of basic compounds, eliminating the need for column priming. An Rtx®-5 Amine column is ideal for analyzing a wide variety of basic compounds, but breakthrough technology also allows the analysis of neutral compounds, adsorptive compounds with oxygen groups susceptible to hydrogen bonding, or even weakly acidic compounds such as phenols. Every Rtx®-5 Amine column is tested to ensure that it exceeds the requirements for analyzing ppm levels of amines, without priming, and to ensure low bleed at maximum operating temperature.