Fast, efficient separations in an economical cartridge format. The design allows rapid substitution of one cartridge for another. The holder is available with either standard fittings or with a universal PEEK tip fitting. The universal fitting gives the user the option of threading the column directly into the detector inlet, reducing system dwell volume. The cartridges are 30mm long, with either 2.1mm or 4.0mm ID. The 2.1mm and 4.0mm ID cartridges have the same outside diameter, so the holder will accept either.